Serum creatinine measurement will be assessed by Isotope-Dilution Mass Spectrometry (IDMS)-standardized method. Creatinine-based eGFR will be calculated using the Berlin Initiative Study 1 (BIS1) equation, which has been developed in a population older than 70 years [46]. ESRD will be defined as GFR < 15 mL/min/1.73 m2 or dialysis [65].

The panel of laboratory parameters to be measured at baseline, 6 and 12 months by local laboratories will also include: complete blood cells count, lipids profile, electrolytes, nutritional status, serum creatinine, urinary albumin and albumin-to-creatinine ratio and urine analysis.

Blood and urine samples will be collected at the time of discharge and at the last follow-up visit, processed and shipped frozen to the INRCA BioGer biobank, where Cystatin C (CysC) [66], Beta-Trace Protein (BTP) and Beta2-Microglobulin will be measured using standardized methods [27, 28].

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