The time of drug administration for both periods was considered as a reference for the study time (t = 0). The blood samples for PK measurements were drawn at 0 (pre-dose), 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 12, 18, 24, 30, 36, 48, 60, 72, and 96 h after dosing. Anticoagulant K2EDTA was added to blood samples and Na2HASO4 was added to prevent dephosphorylation of the DEX-P and BET-P phosphates in plasma. Plasma was separated from blood samples by centrifugation at 4 °C within 30 min after withdrawal. These samples were stored at − 70 °C before further analysis.

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