The drastic spread of COVID-19 in Italy prompted adequate measures for the containment of its transmission [12]. On April 1, 2020 a total number of 110.574 documented cases and 13.155 documented deaths related to SARS-CoV-2 infection were reported, with an increasing trend during the subsequent days and a mortality rate of up to 10% [13]. However, it is of paramount importance to explain the reasons for such a high mortality rate in the Italian general population in order to develop optimal management strategies to face the future. The mean Italian population age may be identified as one of the contributing factors; indeed, Italy has the most elderly population in Europe and the second most elderly population in the world after Japan. The median age of Italian people infected with SARS-CoV-2 infection, and who subsequently died, has been reported to be around 70–75 years, while the average age of patients requiring critical care-support is around 65 years [14]. Moreover, COVID-19 morbidity and mortality strongly depend on the presence of concomitant respiratory diseases. In this context, Italy reported an elevated percentage of patients with a history of severe smoking and high rates of chronic obstructive pulmonary disease as well as cardiovascular/ischemic affections [15]. With regard to the Italian female general population, the mortality rate is reported to be around 5.8% [16]. Nevertheless, assessing the mortality rate in young pregnant women is to date particularly challenging due to the poor data reported on the topic so far.

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