Human plaque single cell sequencing raw data was downloaded from a publicly available databank (https://figshare.com/s/c00d88b1b25ef0c5c788; doi: 10.6084/m9.figshare.9206387) 31. All (1698) macrophages were sub-clustered into three subpopulations by tSNE 32. Three macrophage populations were defined according to a previous report 31. LGALS3/Gal3 gene expression of each macrophage subtype in human plaques is shown as violent plots.

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