Antibodies against AXL, pIGF-1R (Y1135/6), IGF-1R, pSrc (Y416), Src, pMet (Y1234/5), Met, tubulin, and cleaved caspase-3 were purchased from Cell Signaling Technology (Danvers, MA, USA). Antibodies against cleaved PARP were purchased from BD Biosciences (San Jose, CA, USA). Antibodies against pAXL (Y702) were purchased from R&D systems (Minneapolis, MN, USA). Primary antibodies against IGF-1R and actin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Primary antibodies against pIR/IGF-1R (Y1162/3) were purchased from Thermo Fisher Scientific (Waltham, MA, USA). Horseradish peroxidase-conjugated secondary antibodies were purchased from GeneTex (Irvine, CA, USA). Linsitinib, dasatinib, and bemcentinib (R428) were purchased from Selleckchem (Houston, TX, USA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and other chemicals were purchased from Sigma-Aldrich (St. Louis, MO, USA) unless otherwise specified. The detailed information on used primary and secondary antibodies, including vendor, catalogue number, application, and dilution ratio (or concentration) is listed in Table S1.

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