Genes that were differentially expressed between high and median subtypes were identified as DEGs and used for functional enrichment analyses. The analyses were performed using the online gene annotation and analysis tool Metascape (http://metascape.org) 22. Search Tool for the Retrieval of Interacting Genes (STRING, http://string-db.org) online database was utilized for prediction of PPI network of significant DEGs (combined score >0.9). Cytoscape 3.7.2 was utilized to visualize interactive network.

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