cBioPortal (www.cbioportal.org) is an open source platform for exploring, visualizing, and analyzing multidimensional cancer genomics and clinical data 21. The dataset we explored is BC (METABRIC, Nature 2012 & Nat Commun 2016) with a total of 2509 samples, among which 1904 samples with complete mutation and copy number alterations were built to analyze the genomic profiles of hub genes. Genetic mutations in hub genes and their association with overall survival (OS) of BC patients were displayed as Kaplan-Meier plots, and the log-rank test was performed to identify the significance of the differences between the survival curves. When a p value <0.05, the difference was considered statistically significant.

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