Gene Ontology (GO) analysis 13 and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis 14 were performed on the intersecting DEGs using Database for Annotation, Visualization and Integration Discovery (DAVID) version 6.8 15. DEGs enriched in biological processes (BPs), cellular components (CCs) and molecular functions (MFs) were included in the GO analysis (p<0.05).

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