Protein-Protein Interaction (PPI) and miRNA-target interactions (MTIs)

PICKLE (Protein InteraCtion KnowLedgebasE) is a meta-database for the human direct protein-protein interactome, integrating publicly available PPI databases via genetic information ontology 19. A total of 179738 standard and cross-checked PPIs were downloaded from PICKLE. miRNA-target interactions (MTIs) from the experimentally validated MTI database miRTarBase are validated experimentally by reporter assay, western blot, microarray and next-generation sequencing experiments 20. A total of 502652 human MTIs (containing 2599 miRNAs and 15050 target genes) were obtained from miRTarBase.

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