Gene function enrichment analysis, transcription factors, and cancer gene annotation

We used the R package clusterProfiler 15 to perform gene ontology and pathway enrichment analysis. Adjusted p-values less than 0.01 were obtained by the BH method were regarded as statistically significant. The human transcription factor list was downloaded from the supplementary file of Lambert et al. 16.

The oncogene list was obtained from the ONGene database 17 (, and the tumor suppressor genes (TSGs) list was from the TSGene database 18 ( The activation of oncogenes and inactivation of TSGs may be associated with the cancer development.

Note: The content above has been extracted from a research article, so it may not display correctly.

Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.

We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.