DNA extraction and sequencing library were prepared according to the protocols described previously 14, 15. To be specific, 104 and 80 cancer samples were tested with 139-gene panel and 425-gene panel respectively, both of which cover the whole MET exon 14 and the adjacent intron regions, and all essential lung-cancer related genes. All samples were sequenced in a Clinical Laboratory Improvement Amendments (CLIA)- and College of American Pathologists (CAP)-certified genomic testing facility (Nanjing Geneseeq Technology Inc., Nanjing, China). Different types of genetic alterations were called using an internally-validated bioinformatics analysis pipeline 16. Clinical information, including age at diagnosis, sex, disease stage, and treatment history was extracted from the medical records provided by physicians during the service order. Informed written consent was acquired from each patient at the time of sample submission. The study methodologies conformed to the standards set by the Declaration of Helsinki and was approved by the ethics committee.

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