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When the median survival time (MST) cannot be got, we chose mean survival time instead. Student t-tests or the Pearson chi-square tests was adopted on the basis of the variable type to elucidate the correlations between each and/or combined genotypes with clinicopathologic parameters. Kaplan-Meier plots and log-rank tests were calculated by SPSS 20.0 software (Inc, Chicago, IL, USA). The estimation of the crude/adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated by univariate or multivariate Cox regression analysis. All of the above tests were bilateral and P < 0.05 was defined as statistical significance.

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