We enrolled and conducted baseline interviews with 200 young (18–24 years old) female sex workers in the IPrEP study in Kisumu, Kenya, between October 2019 and February 2020. IPrEP is an ongoing open-label, randomized controlled trial providing daily oral pre-exposure prophylaxis (PrEP) for HIV prevention to young female sex workers and comparing the effectiveness, feasibility, and acceptability of two behavioral support interventions to optimize PrEP adherence. Participants will be followed for 24 months. Criteria for trial participation are: (1) no previous diagnosis of HIV infection; (2) being a biological female; (3) age 18–24 years; (4) living or working in study area; (5) intention to stay in study area for 24 months; (6) exchange sex with men for goods, money, favors or other services in past 3 months; (7) no current or recent (within past 3 months) PrEP use; (8) able to complete study procedures in English, Kiswahili or Dholuo; and (9) willingness to be randomized and adhere to PrEP plus adherence support interventions.

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