Data were plotted using Prism 7 (GraphPad). The statistical analysis for each experiment was performed using the test indicated in the relevant figure legend and multiplicity adjusted P-values using the built-in analysis tools of Prism 7. Figures were prepared using Illustrator (Adobe). Unless otherwise indicated, data are represented as mean ± standard error of the mean (SEM) for error bars. Asterisks denote P-value as follows: P < .05 (*), P < .01 (**), P < .001 (***), and P < .0001 (****).

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