We will explore heterogeneity via subgroup analyses. First, we will report within-study subgroup data from our pre-specified subgroups of interest (Tables 2, ,3,3, ,4,4, and and5).5). We will also stratify the meta-analyses by subgroups (between-study analysis) or use other relevant statistical techniques like meta-regression to investigate heterogeneity. For population subgroups, we will use a large majority (i.e. > 80% of participants) to decide the relevant subgroup for each study. We will interpret the plausibility of subgroup differences cautiously using available guidance [130, 131]. Should within- or between-study subgroup analysis not be available or possible for some subgroups, studies with individuals or populations that may require equity (e.g. Indigenous peoples, trauma affected, low income) or other considerations by the Task Force will be noted and the applicability of the interventions to these populations will be assessed.

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