When data required for statistical pooling are not reported by the individual studies, we will contact the corresponding author via e-mail to inquire about the availability of the data. We will contact authors twice, 2 weeks apart, before ceasing contact if we do not receive a response.

For randomized trials, we anticipate that many will report their findings based on a ‘number of individuals screened’ denominator, rather than intention-to-screen calculations using all individuals randomized. Our primary analysis will use outcome data derived by analyzing all individuals randomized (i.e. intention-to-screen). We will extract data as reported in the individual studies using the number randomized as the denominator for each arm. We will also analyze based on the findings as reported in the individual studies, undertaking separate analyses for studies reporting only the number of individuals screened and those reporting on all individuals randomized.

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