We will synthesize the quantitative data separately from the qualitative data. For the quantitative data, we expect to undertake a narrative synthesis given the likely heterogeneity in study designs, exposures, comparisons, and outcomes reported across studies. We will synthesize the included studies and draw conclusions based on the body of evidence using standard methods for narrative syntheses, as described by Popay et al. [126]. Adaptations to standard methodology may be necessary, as our review aims to investigate peoples’ values and preferences, so the outcomes differ, to a certain extent, when compared with intervention or implementation reviews. We will first present an overall synthesis of each included study, including their characteristics and reported findings. We will then describe relationships within and between studies, focusing on our exposure subgroups and comparators of interest and other factors such as methodological quality. As much as possible, we intend to report a best estimate of values and preferences for various exposures and potential moderating factors.

We will analyze the qualitative data following standard procedures for thematic analysis [110, 127]. One reviewer will initially read through the data to familiarize themselves with the prevailing ideas. Next, the reviewer will use line-by-line coding in Microsoft Word to apply one or more codes to each line of text. The reviewer will then compare codes across the data, combine similar codes, categorize common codes into themes, and develop memos for each theme. To reduce the risk of interpretive biases, a second reviewer will review the codes and themes for differences in interpretation. The two reviewers will agree upon the final themes, with the input of a third reviewer if necessary. We will report on each theme narratively.

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