We reviewed individual records of patients followed for PCNSL in two Parisian Hospitals from the national LOC network (La Pitié Salpêtrière and Saint Louis) and selected patients who had a SARS-CoV-2 infection between March 2020, and May 2020. Diagnosis of SARS-CoV-2 infection was based either on a positive real-time polymerase chain reaction (RT-PCR) of nasopharyngeal swab or on lung computed tomography (CT) scans (i.e., ground-glass opacities, multilobe or posterior involvement, bilateral pneumonia distribution [15, 16]). In both hospitals, all patients with PCNSL had systematic screening for SARS-CoV-2 infection with either a RT-PCR screening or a lung CT-scan at the time of admission, regardless of whether they had COVID-19 symptoms. The study was conducted in compliance with the Declaration of Helsinki. Approval was obtained from the local ethics committee (IRB approval 2020CER-202028).

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