The running capacity was evaluated on a treadmill (Tecmachine, Medical Development) at a 4% slope. All mice (4 to 5 months old) were initially acclimatized to the treadmill for 5 days (10 min/day and 12 m/min). The maximal aerobic speed was determined by challenging mice to an exercise of progressively increased intensity. Speed was increased every 2 min and the speed of the last completed running step before exhaustion was considered as the individual maximal aerobic speed. Endurance capacity was determined by challenging mice to a submaximal exercise intensity (60% of the maximal aerobic speed) until exhaustion.

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