Athymic nude mice bearing tumor xenografts were injected intravenously with IR-26 at a dose of 0.3 mg/kg (n = 3). Whole body of mouse optical imaging was taken at day 2 after injection using Kodak In-Vivo Imaging System FX Pro (New Haven, CT) equipped with fluorescent filter sets (excitation/emission, 770/830 nm); all settings were applied as described previously (21). After mice were sacrificed, dissected organs and tumors were obtained for NIR fluorescent imaging at the day of sacrifice.

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