The synthetic route of compound IR-26 was shown in fig. S2. Compounds 2 and 4 were prepared according to the previously reported methods (41). Next, compound 5 was synthesized by an amidation reaction between compound 2 (2.12 g, 10 mmol) and compound 4 (1.25 g, 10 mmol) in the presence of triethylamine (Et3N, 10 mmol) with a yield of 60%, white solid, and melting point of 51° to 52°C. 1H nuclear magnetic resonance (NMR; 400 MHz, CDCl3) δ: 1.49 (m, 2H), 1.69 (m, 2H), 1.86 (m, 2H), 2.27 (t, J = 7.5 Hz, 2H), 3.41 (t, J = 6.7 Hz, 2H), 3.77 (s, 3H), 4.06 (d, J = 5.1 Hz, 2H), 5.99 (s, 1H). Subsequently, alkylation reaction between 2,3,3-trimethyl-3H indole and 5 was carried out under 110°C for 10 hours in 1,2-dichlorobenzene to obtain compound 6 in the form of indole quaternary ammonium salt. Without purification of 6, it was reacted with 7 (1.03 g, 6 mmol) by a condensation reaction in 40 ml of absolute ethanol solution of sodium acetate (0.49 g, 6 mmol) to finally synthesize IR-26 (1.63 g, yield 30%, green sticky solid). Structural characterization was determined by 1H NMR, 13C NMR, and high resolution mass spectroscopy (HRMS).

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