H3K27ac ChIP-seq signal at enhancer peaks, where H3K4me3 was lacking, was used to identify super-enhancers by ROSE algorithm (25). H3K27ac enhancer peaks were stitched if they were within distance of 12.5 kb. Gene annotations were assigned to H3K27ac enhancer peaks (stitched or not, depending on the distance within 12.5 kb or not) if TSSs were within 50-kb distance of peak or if gene regions overlapped with peak.

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