siRNAs of negative control, S100A8 (HSC.RNAI.N002964.12.3), and S100A9 (HSC.RNAI.N002965.12.1) were obtained from Integrated DNA Technologies. siRNA-mediated knockdown was performed as previously described (48). After 3 days of siRNA transfection, cells were tested for tamoxifen-induced transformation.

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