This nationwide study was conducted in all 27 medical centers routinely obtaining cerebrospinal fluid (CSF) and blood cultures from children <24 months old in Israel; sites included 26 hospitals and 1 outpatient health maintenance organization (14). This setting enabled us to cover all culture-confirmed IPD cases among the population of Israel and calculate national incidence. No CSF cultures and <1% of blood cultures were obtained outside these centers. Data in our study were for IPD episodes identified since 2009.

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