Our data derive from several ongoing, population-based, active surveillance projects conducted by the Pediatric Infectious Disease Unit, Soroka University Medical Center (SUMC) during 2009–2017. We defined 2 periods: early PCV (2009–2011) and late PCV13 (2015–2017). SUMC is the only hospital in southern Israel providing healthcare to the entire region, which enables us to conduct population-based studies.

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