The correlations between abundance levels of 133 metabolites was determined using Spearman’s correlation coefficient for each pair of metabolites within each tissue. The overall distributions of correlations squared, i.e. variance explained, were plotted for relevant pathways in each tissue type. Strong correlations defined as Spearman’s correlation coefficient of more than 0.5 were illustrated using Circos generated by Pinet Server (78) where nodes denote metabolites, edges represent correlations (with width proportional to the strength of correlation), and the size of a node represents the number of edges originating from that node, i.e. its degree.

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