We quantified how much of ganciclovir’s effect on clinical outcomes could be attributed to its effect on VL kinetics. This quantity is called the proportion of treatment effect captured by the surrogate (PCS) (23). A PCS higher than 63% is considered “moderate;” PCS higher than 85% is “substantial”; and PCS higher than 93% is “almost perfect” (23). Details regarding the PCS method and our implementation are provided in the Supplemental Methods.

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