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Animal experiments were approved by our institutes and complied with the Guideline for Animal Care at the Shanghai Jiao Tong University School of Medicine and the State Key Laboratory of Experimental Hematology. Human samples were supplied by the Department of Hematology at the First People’s Hospital, Xinhua Hospital, or Tongren Hospital, Shanghai Jiao Tong University School of Medicine. Written informed consent was obtained from the patients and approved by the Ethics Committee for Medical Research (IRB) at Shanghai Jiao Tong University School of Medicine.

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