Antibodies against phospho-histone H3 (S10), cleaved caspase-3 (Cl-cas3), p21, LC3B, phospho-ERK (T202/Y204), ERK, phospho-eIF2α (S51), PERK, ATF4, phospho-p70S6 kinase (T389), phospho-Akt (S473), Akt, phospho-4E-BP1 (S65), 4E-BP1, phospho-mTOR (S2448), and mTOR were purchased from Cell Signaling Technology. Antibodies against RGS2, Cyclin D1, CDK4, p27, Actin, eIF2α, GADD34, CHOP/GADD153, ubiquitin, phospho-p38 (Y182), p38, OctA-probe, and His-probe were purchased from Santa Cruz Biotechnology. Antibodies against Ki67 and PCNA were purchased from Abcam. Rabbit polyclonal anti–phospho-PERK (S713) antibody and CFSE cell division tracker kit were purchased from BioLegend. Rabbit polyclonal anti-RGS2 and anti-ATF4 antibodies were purchased from Proteintech. A mouse monoclonal anti-cleaved PARP antibody was purchased from BD Biosciences. HRP-conjugated secondary antibodies were purchased from GeneTex. Additional information on antibodies used, including source and catalog/clone number, is listed in Supplemental Table 3. Pc, sildenafil citrate, and tadalafil were purchased from Selleck Chemicals. Pm was purchased from LC Laboratories. Rapamycin was purchased from Tocris Bioscience. Cycloheximide was purchased from Merck Millipore. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was purchased from MP Biomedicals. db-cGMP was purchased from Cayman Chemical. Other chemicals, including Cs, etoposide, NAC, MG132, TG, and crystal violet, and the PKH26 Red Fluorescent Cell Linker Kit, were purchased from MilliporeSigma.

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