All experimental procedures using mice were run in parallel with proper controls (sex- and age-matched littermate controls when possible) to detect experimental variabilities. Analysis of grouped data was not blinded, and no samples were excluded. Error bars indicate the mean ± SEM. With the exception of the GSEA, statistical analysis was performed using GraphPad Prism 6 (GraphPad Software), with ordinary 1-way ANOVA for multiple comparisons and Kaplan-Meier survival analysis for survival comparisons.

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