The patients and the other members of their family were living in Palestinian territory, and were followed up in Israel. Informed consent was obtained in their country of follow-up, in accordance with local regulations and the requirements for institutional review board approval from Rockefeller University and INSERM. Experiments were conducted in the United States and France, in accordance with local regulations and with the approval of the institutional review board of Rockefeller University and INSERM, respectively. Detailed patient clinical information is provided in Supplemental Methods.

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