All tissues were collected in accordance with local ethics regulations, and patients provided written informed consent prior to sample collection. The study was approved by the Cantonal Ethics Committee of the Canton Zürich, Switzerland (approval no. 2018-02193 and KEK-ZH-647) and the local ethics committee of the Friedrich-Alexander-University (FAU) of Erlangen-Nürnberg. All animal experiments were performed according to Swiss animal welfare legislation and approved by the local veterinary office (Veterinäramt des Kantons Zürich; license nos. 239/2016 and 179/2019).

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