A1cf–/– and Apobec1–/– mice were on a background of C57BL/6NJ or C57BL/6J, respectively (13, 52). For high-fat diet studies, mice were fed a high–trans-fat, high-fructose diet (TD.06303, Envigo) for 6 months. Unless noted otherwise, mice were fasted for 4 hours and injected with 100 mg/kg of BrdU (Sigma-Aldrich) 2 hours before study. Littermate controls were used in all experiments.

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