WT, lmnaH222P+/-, and lmnaH222P/H222P mice were maintained in a 129S2/SvPasCrl genetic background with ad libitum food and water for 12-hour light/12-hour dark cycles. Besides embryos, only male adult mice (2–6 months old) were used in the study. The animal experiments were performed according to the guidelines from Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes.

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