All statistical analysis was performed using GraphPad Prism software, version 8.0.2 (GraphPad Software). All data are presented as the mean ± SEM. Unless otherwise noted, all grouped comparisons were made by 1-way ANOVA with Tukey’s correction, and all pairwise comparisons by 2-sided Student’s t tests, depending on experimental design. For all tests, P values of less than 0.05 were considered significant, and those over 0.05 were considered nonsignificant.

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