TCGA human HCC cohorts and data processing.
This protocol is extracted from research article:
CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis
J Clin Invest, Jan 4, 2021; DOI: 10.1172/JCI133525

An HCC cohort containing 370 cases (including 168, 84, 82, and 6 cases at tumor stage I, II, III, and IV, respectively) was retrieved from The Cancer Genome Atlas (TCGA) database, queried by CLIC1, HCC, survival rate, and gene expression as keywords. The expression of CLIC1 in patients was sorted and survival plots were analyzed by using the UCSC Xena Functional Genomics Explorer ( and SurvExpress ( The cumulative survival curves for talin, vinculin, paxillin, and FAK were performed by using the software of Kaplan-Meier Plotter ( (34).

Note: The content above has been extracted from a research article, so it may not display correctly.

Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.

We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.