All of the articles on C1-INH–HAE were analyzed up to December 2019 without setting limits around the commencement year of the SR. To identify all the studies that included psychological dimensions related to the illness experience, both medical data bases (PubMed and Embase (Excerpta Medica dataBASE, Elsevier, Amsterdam)) and a psychological data base (PsycInfo (American Psychological Association, USA)) were examined. The keywords (KWs) used for searching PubMed and Embase were the following: “hereditary angioedema,” “psychology,” “stress,” “anxiety,” and “depression.” These KWs were selected from a preliminary bibliography12,18 as psychological processes relevant to the C1-INH–HAE illness experience. Only the KWs that returned results from the aforementioned data bases are shown, whereas any KWs used without returning results (e.g., “psychological correlates”) were not reported. The KWs search and the analysis were performed on the whole manuscript file.

L. Savarese made substantial contributions to the conception and design of the study, acquisition of data, analysis, and interpretation of data; I. Mormile made substantial contributions to the conception and design, acquisition of data, analysis, and interpretation of data; M. Bova drafted the article and reviewed it critically for important intellectual content; A. Petraroli drafted the article and reviewed it critically for important intellectual content; A. Maiello made substantial contributions, acquisition of data, analysis and interpretation of data, and review of the manuscript; G. Spadaro gave final approval of the version to be published and agrees to be accountable for all aspects of the work related to its accuracy or integrity; and M. Francesca Freda gave final approval of the version to be published and agrees to be accountable for all aspects of the work related to its accuracy or integrity.

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