All adults aged between 40 and 70 years who were registered with the UK National Health Service (NHS) and living within 25 miles of 22 assessment centres across England, Scotland and Wales were invited to participate in UK Biobank at baseline. The achieved sample of 502,536 people had a response rate of 5.5% (Sudlow et al., 2015) and an age range of between 37 and 73. Participants were recruited between March 2006 and October 2010 (Sudlow et al., 2015) and for each participant baseline assessments consisted of a single visit lasting approximately two to three hours, including a computerised self-completion touch screen questionnaire, nurse interviews, and physical measurements. For all participants, the date and cause of death were sought from death certificates held within the National Health Service Information Centre (England and Wales), and National Health Service Central Register Scotland. At the time of analysis, mortality data were available up to the middle of February 2018 for England and Wales and until June 2017 for Scotland. Data for Hospital admission records for self-harm were only available for participants in England and for the period up to March 2015, thus analyses for self-harm were restricted to those who attended a Biobank assessment centre in England (n = 448,811). This study is covered by the generic ethical approval for UK Biobank studies from the National Health Service National Research Ethics Service (June 17, 2011; Ref 11/NW/0382). Participants provided electronic informed consent for the baseline assessments and the register linkage.

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