TBI was induced in mice by a weight-drop method, as previously described 19. In brief, mice were anesthetized with isoflurane, and were then placed on the platform under the weight-drop device. In order to expose the skull, a 1.5 cm midline longitudinal scalp incision was made. The left anterior frontal area (the exact location is 1.5 mm lateral to the midline on the mid-coronal plane) was used as the impact area, a 200 g weight was released above the impact area from a height of 2.5 cm. Then, the skin incision was sutured immediately, and the mice were returned to their own cages.

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