Age, glucose, and lipid metabolic parameters (TC, HDL-C, TG, LDL-C, FPG, and HbA1C) were compared between the T2DM and NDM groups using Student's t test. Sex in the T2DM and NDM groups was compared using the Chi-square test. All polymorphic loci were tested for deviation from the Hardy-Weinberg equilibrium in the NDM group with a threshold of 0.05. Risks were estimated by odds ratios (OR) with 95% confidence intervals (95% CI). Linkage disequilibrium (LD) among these SNPs was estimated. The LD coefficient D was calculated using SHEsis software 33, 34. The distribution and differences in the haplotypes between the T2DM and NDM groups were determined using SHEsis software. Haplotype frequencies <0.03 were ignored in the analysis 33, 34. The association between each SNP and T2DM was analysed for mode of inheritance using SNPStats 35. Power-analysis was performed using power and sample size calculations 36. Bonferroni correction for multiple comparisons was used for each SNP and haplotype.

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