Construction of lncRNAs-miRNAs-mRNAs network in cisplatin resistant NSCLC cells

PPI networks can provide information on the molecular mechanism. The same to us, lncRNA-miRNAs-BAX network were established by cytoscape3.7.2 software obviously (http://www.cytoscape.org/) 24. Every type of RNAs all represented different nodes and the relationships between these genes were considered to be edges. In this circumstance, BAX, 4miRNAs, lncRNA XIST were all visualized in this ceRNA family. LncRNAXIST regulated the miRNAs by BAX, participating in P53 signaling pathway in cisplatin resistant NSCLC (Figure Figure11).

The detailed process of constructing a ceRNA network about lncRNAs- miRNAs - mRNA.

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