According to the targeted molecule BAX, we found miRNAs, which commonly regulated BAX from miRDB 26 (http://www.mirdb.org), Targetscan 26 (http://www.targetscan.org), Starbase 27 (https://starbase.sysu.edu.cn/), miRWalk (http://mirwalk.umm.uniheidelberg.de/) 28. Then, we showed 8 miRNAs regulating BAX in only four databases by Venn software, such as hsa-miR-3681-3p, hsa-miR-766-5p, hsa-miR-525-5p, hsa-miR-4640-3p, hsa-miR-128-3p, hsa-miR-216a-3p, hsa-miR-520a-5p, hsa-miR-214-3p. But these miRNAs were not all related to the survival of patients. Later, 4miRNAs (hsa-miR-4640, hsa-miR-520a-5p, hsa-miR-214-3p, hsa-miR-525-5p) were obviously related to overall survival 29 (P<0.05) by the Kaplan Meier plotter software (https://kmplot.com) 24.

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