Hap Map and NCBI-db SNP databases were used to retrieve KRAS, HRAS, and NRAS SNPs. Haploview 4.2 software was used to filter tag SNPs with r2>0.8, MAF (minor allele frequency)>10%, D'= 1, and CHB (Han population in northern China) as parameters. SNPs are preferably sites of missense mutations, introns in the regulatory region are the second choice. A total of 6 SNPs was selected in this study, rs712, rs7315339, and rs12427141 of the KRAS gene, rs12628 of the HRAS gene, and rs2273267 and rs14804 of the NRAS gene.

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