All chest CT scans were obtained using four multi-detector CT scanners: SOMATOM go.Top (Siemens Healthineers, Germany), SOMATOM Sensation 16 (Siemens Healthineers, Germany), Light Speed16 (GE Medical Systems, USA) and Asteion (TOSHIBA, Japan). Two chest radiologists with 10 and 8 years of experience who were blinded to the clinical data evaluated the CT findings in consensus. For each of the individuals, the first and last chest CT images were evaluated for the following characteristics based on the Fleischner Society Nomenclature recommendations 30 and similar studies 24,31: ground-glass opacity (GGO), consolidation, linear opacities, interlobular septal thickening, crazy-paving pattern, “spider web sign”, subpleural curvilinear line, thickening of the adjacent pleura, lymphadenopathy, pleural effusion and pericardial effusion. What's more, the margin definition of the max lesion, distribution, location and extent of abnormalities were recorded 24.

All the follow-up CT images were evaluated for: 1) the patterns of evolution throughout the series of CT scans 24, 2) the long diameter (cm) and density (HU) of the max lesion of the lung, 3) the number of segments involved.

The median volume CT dose index and dose-length product for CT acquisition were 11.1 mGy (range, 5.5-18.4) and 364.8 mGy∙cm (range, 215-750), respectively, corresponding to an effective radiation dose of 5.1 mSv (range, 3.0-10.5) (using a standard conversion factor for chest CT of 0.014 mSv/mGy∙cm).

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