The study was approved by the Animal Care Ethics Committee of the Use of Laboratory Animals at Shanghai University of Traditional Chinese Medicine. The 8-week- and 40-week-old male SAMP8 mice were purchased from the model animal research center of Zhishan Institute of Healthcare Research Co., Ltd. (Beijing, China). All the mice were kept in an SPF grade animal facility at 24°C with a relative humidity of 50%-60%, and in a light/dark cycle of 12 h/12 h.

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