Differential mRNA expression of MYC and its relationship with prognosis
This protocol is extracted from research article:
MYC dysfunction modulates stemness and tumorigenesis in breast cancer
Int J Biol Sci, Jan 1, 2021; DOI: 10.7150/ijbs.51458

We used ONCOMINE (http://www.oncomine.org), UALCAN (http://ualcan.path.uab.edu), bc-GenExMiner (http://bcgenex.ico.unicancer.fr) and Kaplan-Meier plotter (http://kmplot.com/analysis/) databases to explore the differential mRNA expression of MYC and its relationship with prognosis 61-62. Firstly, we used UALCAN databases to observe the pan-cancer analysis of MYC mRNA expression. Secondly, we used UALCAN and bc-GenExMiner database to explore the differential mRNA expression of MYC in breast cancer subtypes and TNBC subtypes. Finally, Kaplan-Meier plotter was utilized to analyze the interrelation of relapse-free survival (RFS) curves of breast cancer patients with high and low expression of MYC.

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