Simulations of the HF female population predicted that CQ + AZ therapy could induce arrhythmic dynamics in a minority of cells (85 of 1,000 cells). To assess why individual cells within the population were either susceptible or resistant to arrhythmias, we performed logistic regression analysis on the population results. 27 , 28 Each cell in the simulated population was labeled as either a 0 (no arrhythmic dynamics) or a 1 (arrhythmic dynamics) and the MATLAB function MNRFIT was used to derive a logistic model that can predict the probability of arrhythmia from the parameter values in each cell. This can be used to rank‐order parameters based on their importance in governing whether arrhythmic dynamics occur. 27 , 28

Model code is available at the first author's github repository:

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