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Relevant literatures were collected in the Web of Science Core Collection (WoSCC) database which was widely used in bibliometric analysis 25,26. The search query was “TS (Topics)= (“cAMP” or “cyclic adenosine monophosphate” or “cyclic AMP” or “protein kinase A” or “PKA” or “EPAC*” or “CNGC”) and TS= (“tumor*” or “cancer*” or “carcino*” or “onco*”)” (the symbol “*” is a retrieval symbol of WOS advanced retrieval, which means to search for words prefixed with the word before “*”). Research results were restricted by language (English) and document type (Article). Publication year was restricted from 2009 to 2019. Literature search was completed within a day to avoid bias caused by database updates. A total of 4590 articles were retrieved. Considering that the word “camp” has the meaning of vacation camp, the retrieved literature was screened, and the articles that the definition of “camp” is not cyclic adenosine monophosphate were excluded. 284 articles and duplicate literature were screened out, so a total of 4306 articles were included in this analysis.

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