For patients from nCRT group, neoadjuvant therapeutic settings included induction chemotherapy followed by concurrent chemoradiation (induction CT+CCRT) and CCRT alone. Induction CT was based on the regimen of SOX as described above for 2-4 cycles. For CCRT planning, patients received two irradiation dose levels of planning target volume (PTV) and PTV boost of 40.04 and 45.1 Gy 22 fractions plus S-1 (80 mg/m2/d) administrated on radiotherapy days. Radiotherapy was delivered to the entire stomach and draining regional lymph nodes using three-dimensional (3D) conformal techniques, intensity-modulated radiotherapy (IMRT).

CT-scan and /or positron emission tomography (PET) scan was performed during the therapy to monitor the clinical response. The tumor response was classified according to the Response Evaluation Criteria in Solid Tumors (RECIST) 10 and the adverse events of chemotherapy were assessed according to the National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE version 4.0).

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