Relevant studies published before August 26, 2020 was comprehensively searched through the English databases PubMed, Cochrane Library, Web of Science, and EMBASE. We used “TBI” and “miRNA” as the main key words and the following strategy to search PubMed: (((“Brain Injuries, Traumatic”[Mesh]) OR (((((((((((((((Brain Injury, Traumatic[Title/Abstract]) OR Traumatic Brain Injuries[Title/Abstract]) OR Trauma, Brain[Title/Abstract]) OR Brain Trauma[Title/Abstract]) OR Brain Traumas[Title/Abstract]) OR Traumas, Brain[Title/Abstract]) OR TBI (Traumatic Brain Injury)[Title/Abstract]) OR Encephalopathy, Traumatic[Title/Abstract]) OR Encephalopathies, Traumatic[Title/Abstract]) OR Traumatic Encephalopathies[Title/Abstract]) OR Injury, Brain, Traumatic[Title/Abstract]) OR Traumatic Encephalopathy[Title/Abstract]) OR TBIs (Traumatic Brain Injuries)[Title/Abstract]) OR TBI (Traumatic Brain Injuries)[Title/Abstract]) OR Traumatic Brain Injury[Title/Abstract]))) AND ((“MicroRNAs”[Mesh]) OR (((((((((((((((((MicroRNA[Title/Abstract]) OR miRNAs[Title/Abstract]) OR Micro RNA[Title/Abstract]) OR RNA, Micro[Title/Abstract]) OR miRNA[Title/Abstract]) OR Primary MicroRNA[Title/Abstract]) OR MicroRNA, Primary[Title/Abstract]) OR Primary miRNA[Title/Abstract]) OR miRNA, Primary[Title/Abstract]) OR pri-miRNA[Title/Abstract]) OR pri miRNA[Title/Abstract]) OR RNA, Small Temporal[Title/Abstract]) OR Temporal RNA, Small[Title/Abstract]) OR stRNA[Title/Abstract]) OR Small Temporal RNA[Title/Abstract]) OR pre-miRNA[Title/Abstract]) OR pre miRNA[Title/Abstract])).

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